After being disappointed with Enter the Gungeon I decided to peek on Nuclear Throne, a game people say it shares many similarities.
It seens to also share some of the same problems, i.e, a slow, repetitive start with a ectic end which will kill you quickly and send you back to the boring beginning.
People should take some hints from Isaac. Isaac start is slow but it's SHORT so you eat over them quickly. It may also can give you some game-winning items so you can quickly decide if a run is worth or quit the game and try for better luck next time.
Gonna try new games now, maybe Rollers of the Realm or Factorio...