Am I the only one who remembers that there was an entire character arc where Spider-Man grew six additional arms and then further mutated into a giant Man-Spider monster? He kidnapped people to eat them.
Being Spiderman is cool and all, but have you tried being Italian Spiderman?
His powers include:
Boomerang mustache.
Flight.
Being able to outrun a motorcycle.
Having a shotgun.
Can stare at chickens until they lay packs of your favorite cigarette brand.
Becoming 100 feet tall.
TF1 Engineer said, that's more biology than ngineerin. If only there was a Angie knew a TF2 Medic.....Also: if you irradiate a spider you just get a dead spider. And then you bite it and turn into the actual Spiderman Villain "The Thousand" who murders children and wears their skin. Like Spy
Spy already effectively has two superpowers. There should be some limits to a spy's disguise, but it is good enough to count. The spy's invisibility watch is there too. Engineer isn't exactly Tony Stark, but honestly the 1960's Engineer is more impressive than the 1970's Iron Man.
Or we could always look at getting powers from some ancient item empowered by a Divine Entity.
Juggernaut, Moon Knight, Black Panther, Ghost Rider, every "Spider-man" (if you believe that one story arch).
That said, how about Angie just teleport some bread and they can get radioactive bread powers? (those green growths on the spider sure look like the not-cancer bread's beauty marks)