All expected problems which may arise with a game which demands you to connect to a server happened. At this point, anyone suffering from it had plenty of warning.
I guess if you don't mind the problems, or is willing to risk, go ahead and play the game.
For me, the mix of small land size, Origin, internet requirement AND no save files is just too much. I could take maybe one or two of these but it's just too much bad shit bundled together.
The idea of networking with close cities to help each other is a nice idea, but could be emulated with just an AI. Playing with friends and planning together a region is nice and all but chances are people would stop playing and the player would end up alone surrounded by ghosts towns.
Well, there is always the previous SimCities to play...