The really memorable memes will still pop up occasionally even after their main run, but people have short attention spans, so the joke is only funny for so long. That said, the lady yelling at cat meme has had a spectacularly good run.

Haha, good one, thinking Ugandan Knuckles hasn't been going strong for 2 years now!

Dickbutt and Woman yelling at a cat are eternal thought.

I think OK, boomer is the most annoying one that's gone around for a while. I don't know what it is but I find it super irritating.

OK boomers make older folks angry because the millennials do not listen but agree in a way to say "ok, but shut up". Sadly, millennials don't get they are at the bottom of the food chain but for companies that are willing to sell trash (nike, addidas, apple...)

remember when memes were good?
pepperidge farm remembers!

Here's the weird thing about the OK Boomer phrase: It's making older folks angry but it's not even a real insult. It's just the equivalent of kids saying "yeah, whatever, old-timer." ...It's just mild ribbing yet it's legitimately getting folks huffy and upset.

Fed up != stale. After all, the people who got fed up with it are likely not the same as the people perpetrating it.

yeah, it's not a meme from high quality. More something to anoy other people.

Is iAlso something like iPad? Won't iApple sue you, Jo?

I know some people who say they are already fed up with Ok Boomer

I don't know, the 2 meme you pictured in this comic already got a life spam longer than months. Think Uganta Knucle was hot for about 3-5week, and OK boomer is still hot (+4 week?)